Pharmaceutical formulations refer to the process of designing and producing medicinal products in specific dosage forms to ensure safe and effective delivery of active pharmaceutical ingredients (APIs) to patients. Formulations are tailored to meet diverse patient needs, considering factors such as route of administration, dosage strength, stability, and patient compliance. Common dosage forms include tablets, capsules, syrups, injections, creams, and patches. Formulation development involves selecting appropriate excipients, such as binders, fillers, disintegrants, and preservatives, to optimize drug delivery and stability. Techniques such as wet granulation, dry granulation, and direct compression are employed to prepare solid dosage forms, while various emulsification and dispersion methods are used for liquid formulations. Pharmaceutical formulations undergo rigorous testing and evaluation, including physicochemical characterization, stability studies, and in vitro/in vivo performance assessments, to ensure product quality, safety, and efficacy. Collaboration between formulation scientists, pharmacists, chemists, and regulatory experts is essential for developing, optimizing, and commercializing pharmaceutical formulations. Continuous advancements in formulation technology, drug delivery systems, and manufacturing processes contribute to the development of novel and improved pharmaceutical products to meet healthcare needs.
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Thomas J Webster, Brown University, United States