Chemistry World Conference, September 06-08, 2021 | Rome, Italy

Dear congress visitors, it is an honor and pleasure to welcome you at the Chemistry World Conference 2021. Climate changes and environmental problems force chemists to change perspective on industrial development. Being “green” does not merely imply to assess efficient purification treatments of polluted effluents or to reduce the environmental impact of production processes. In fact, “green chemistry” is rather an ethical approach which induces us to design molecules, materials, products and processes in a resource-efficient (both in terms of mass and energy) and safer way for humans and the environment. The industrial implementation of this concept will be reality when the novel “green” processes will be competitive towards the traditional ones in terms of efficiency and yield. Our efforts recently produced admirable results in this regard, and in some cases the existence of traditional and still operating plants seems to be the only reason hindering the implementation of novel and “greener” systems. However, we still have a long way to go. In particular, I wish stronger collaboration between Academia and Industry and interdisciplinary approaches across different research fields. This is the only way to solve the complex challenges of our future.

Chemistry World Conference, September 06-08, 2021 | Rome, Italy

Dear congress visitors, it is an honor and pleasure to write a few welcome notes.

Natural substances play major roles as molecule signals as well as molecules involved in defense mechanisms during intra- and interspecific interactions. Chemical interactions are of great interest in different fundamental and applied fields, i.e.,
-    biodiversity protection,

-    plants, macro- and microorganisms (fungi, bacteria...) as potential resources for human health and nutrition,
-    Potential impacts of natural substances on human health, chemical ecology, ecosystem processes…

Since many years research involves in finding bioactive natural compounds from plants, macro- and microorganisms (extraction process, purification of extracts, identification of primary and secondary metabolites, assays; chemical and biological screening of natural substances materials).

Today, analytical tools have been developed to explore chemo-diversity as a whole but also to study previously unexplored resources or re-study minority compounds of some resources. This renewal in the natural substances chemistry opens the door to a new air in the search for compounds of interests.

Chemistry World Conference, September 06-08, 2021 | Rome, Italy

Dear visitors of the Chemistry 2020 conference, it is an honor and a pleasure to write some welcome notes. The rapid development of analytical and instrumentation techniques has allowed great progress in our understanding of the chemistry and function of nutritional components.

Among the phytochemicals, Betainized Compounds are a group of low molecular weight compounds, derived from amino acids and imino acids in which the nitrogen atom is fully methylated.

In plants, these substances tend to accumulate in the cytoplasm and intercellular fluids in which they exert protective functions on the structures of proteins, nucleic acids and cell membranes in response to abiotic stress.

Plants express characteristic patterns and betainized compounds levels based on their species.

Some betaines are of particular interest in the human diet for maintaining health. For example, Glycine betaine has the biological role of the methyl donor in man for the formation of methionine from homocysteine thus counteracting the accumulation of homocysteine in plasma, which constitutes a risk factor for diseases.

Recently, a group of betainized compounds have been suggested to play a role in health effects in relation to a vegetable and fruit consumption or Mediterranean diet.

The content of betainized compounds appears to be species specific and can help to characterize vegetable sources and their derivatives, such as fruit juices.

Chemistry World Conference, September 06-08, 2021 | Rome, Italy

Dear congress visitors, it is an honor and pleasure to write a few welcome notes. In the ‘Medicinal Chemistry and Drug Discovery’ session we will discuss the new developments in the modern drug discovery process. This process relies heavily on computational methods, in comparison to ‘old school’ methods where the ‘try and error’ dominated. The modern drug discovery processed are based on rational drug design, which is the inventive process of finding new medications based on the available experimental data and molecular modelling techniques. Computer-aided drug discovery (CADD) allows application of computer modelling techniques to the drug design process and is involved in almost every aspect of drug discovery and design today. This includes, but is not limited to the validation of druggable targets, virtual screening, the optimization of lead compounds, characterizing of protein-water-ligand and protein-protein interactions, providing estimates of binding affinities, determining ligand energies and bioactive conformations, refinement of molecular geometries, scoring docked protein–ligand poses, structure–activity-relationship (SAR) analysis and ADMET prediction. This is largely a consequence of significant improvements in computing power/speed, which has led to advances in algorithm development and new applications of CADD methods.