Absorption Distribution Metabolism Excretion (ADME) studies are pivotal in understanding the fate of drugs within biological systems. These studies provide comprehensive insights into how a drug interacts with the body, from its entry into the system to its eventual elimination. ADME studies are integral components of drug development and regulatory approval processes, ensuring safety, efficacy, and optimal dosing strategies.
Beginning with absorption, ADME studies investigate how drugs are absorbed into the bloodstream after administration. This includes understanding the mechanisms of absorption, such as passive diffusion, active transport, or facilitated diffusion, depending on the drug's properties. Factors influencing absorption, such as gastrointestinal pH, surface area, and blood flow, are meticulously analyzed to predict and optimize drug bioavailability.
Distribution examines how drugs are disseminated throughout the body following absorption. This involves understanding how drugs bind to plasma proteins, penetrate various tissues, and cross physiological barriers like the blood-brain barrier. Distribution studies shed light on drug concentrations in different organs and tissues, aiding in determining optimal dosing regimens and potential tissue-specific effects.
Title : Eliminating implant failure in humans with nano chemistry: 30,000 cases and counting
Thomas J Webster, Brown University, United States
Title : Synthesis of chitosan composite of metal organic framework for the adsorption of dyes, kinetic and thermodynamic approach
Tooba Saeed, University of Peshawar, Pakistan
Title : Synthesis, ADMET, PASS, molecular docking, and dynamics simulation investigation of novel octanoyl glucoopyranosides & valeroyl ribofuranoside esters.
Hasinul Babu, University of Chittagong, Bangladesh
Title : Prospective polyoxometalate-based covalent organic framework heterogeneous catalysts
Arash Ebrahimi, Comenius University in Bratislava, Slovenia
Title : Utilizing Generative AI for Interactive Borane Modeling: Insights from Wade's Rule in Undergraduate Education
Mai Yan Yuen, The University of Hong Kong, Hong Kong
Title : Molecularly imprinted polymer-bimetallic nanoparticle based electrochemical sensor for dual detection of phenol iosmers micopollutants in water
Melkamu Biyana Regasa, Wollega University, Ethiopia