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HYBRID EVENT: You can participate in person at Barcelona, Spain from your home or work.

6th Edition of

Chemistry World Conference

June 18-20, 2026 | Barcelona, Spain

Chemistry 2026

New pentacyclic triterpene from potentilla atrosanguinea Lodd. As anticancer agent for breast cancer targeting estrogen receptor

Speaker at Chemistry World Conference 2026 - Amit Kumar
University of Punjab, India
Title : New pentacyclic triterpene from potentilla atrosanguinea Lodd. As anticancer agent for breast cancer targeting estrogen receptor

Abstract:

One new (compound 3) along with two previously known ursane type triterpenoids (compounds 1 and 2) were purified by chromatographic techniques from ethyl acetate extract of aerial parts of Potentilla atrosanguniea and characterized by HRMS, 1D and 2D-NMR. Compounds 1 (ursolic acid), 2 (euscaphic acid) and 3 (3α,20α-dihydroxy 2-oxo-urs-12-en-28- oic acid) were tested for their antiproliferative activity along with standard bazedoxifene. Compounds 1 and 3 were found to be of higher activity (3.71 and 6.05 μg/mL) as compared to compound 2 and bazedoxifene (IC50: 24.53 and 17.87 μg/mL). Anti-estrogenic activity of three compounds on breast cancer (BC) were studied in vitro by accessing their antiproliferative activity and binding with estrogen receptor alpha (ER-α). All three compounds have effective binding affinity towards ER-α and decreased cell growth by downregulating the expression of mRNA and its translational protein as tested by semi-qRT- PCR and western blotting. In terms of effectiveness compounds 1 and 3 were found more active due to their antiproliferative, and antiestrogenic activity as compared to standard bazedoxifene.

Biography:

Dr. Amit Kumar holds a Ph.D. in Pharmaceutical Sciences (Central University of Punjab, 2025), an M. Pharmacy in Pharmacognosy (2013), and a B. Pharmacy (2011) from Punjabi University, Patiala, with GPAT qualifications in 2011 and 2012. He has served as Assistant Professor at several institutes, including Chitkara College of Pharmacy, and held research positions at the Public Health Foundation of India and CSIR-funded projects. Dr. Kumar is skilled in advanced analytical techniques, extraction methods, molecular biology (ELISA, western blotting), computer-aided drug design, high-throughput screening, and In vivo studies.

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