Green chemistry protocol for the synthesis of some new scaffolds of isoxazolidine & isoxazoline derivatives via 1,3-dipolar cycloaddition reaction and potential biological activities of the cycloadducts

Title : Green chemistry protocol for the synthesis of some new scaffolds of isoxazolidine & isoxazoline derivatives via 1,3-dipolar cycloaddition reaction and potential biological activities of the cycloadducts

Abstract:

One of the excellent examples of spin trapping reagents is nitrones which plays fundamental role in the synthesis of five-membered heterocyclic ring compounds (commonly called isoxazolidine and isoxazoline derivatives) via 1,3-dipolar cycloaddition reactions which are an integral part of many natural products. The medicinal activities of these heterocyclic compounds always finds a tremendous interest to the synthetic organic chemists as they found to exhibit antibacterial, anticonvulsant, antibiotic, antituberculer, antifungal and anticancer activities.Except green chemistry methodologies, majority of the reported procedures for the synthesis of isoxazolidine and isoxazoline derivatives require drastic experimental conditions like high temperature and long reaction times. In addition, these reactions found to suffer from selectivity and also there are possibilities of poor yields as well as development of side products.Majority of these conventional procedures for the synthesis of isoxazolidine and isoxazoline derivatives are replaced successfully nowadays with the inception of green chemistry procedures like mechanochemistry (solid phase reaction), reactions conducted “in water” & “on water”, microwave induced reactions and many more techniques. In the present work, few excellent examples based on stereoselective 1,3-Dipolar cycloaddition reactions using green chemistry protocols have been reported. Good to excellent yields, minimum reaction time, fast & simple isolation of products, environment friendly reaction conditions and stereoselectivities in the reported reactions will certainly attract researchers working in this domain.

Keywords: Stereoselective 1,3-Dipolar cycloaddition reaction, New approaches, Green chemistry methodologies, Anticancer activity

Biography:

Professor of Organic Chemistry at Sikkim Government College (An Extension Centre of Sikkim University),Gangtok, Sikkim, India with 30 years of teaching experience in teaching Undergraduate and Post graduate Chemistry students. Has active research experience of  30 years in synthetic organic chemistry in the field of “Nitrone cycloaddition reactions and their further applications following green chemistry methodologies”. Has established few environment friendly greener methodologies along with atom efficient reactions in the synthesis of few novel isoxazolidine and isoxazoline derivatives using new nitrones via 1,3-dipolar cycloaddition reactions. These novel isoxazolidine and isoxazoline derivatives are found to have vast synthetic potential as they could be used as precursor for the synthesis of a variety of new organic molecules including peptides with potential biological activities. Supervisor of research scholars leading to Ph.D degree for 24 years (Awarded 8 Ph.D scholars & 2 are working). Has 21 years of administrative experience as “Head of Department” in the institution. Former “Overseas Fellow” at the Cardiff University, Cardiff, Unied Kingdom in 2019. Has sufficient expertise in conducting DST/CSIR/UGC national research projects. Has published 70 nos of peere reviewed research publications  (Scopus & WOS) in international and national journals of high repute and impact factors. Honorary referee and editorial board member for reviewing research manuscripts for various international and national journals with good impact factors. Has authored two books on the “Synthetic applications of nitrone cycloaddition reactions”. Has been awarded with many international and national awards. Has been associated as “Life member” with various international and national scientific organizations. Has presented research papers in various international and national conferences as “Invited Speaker” in UK, Germany, Greece, France and India. Has performed activities as “Organizing Commettee Members” (OCM) in international conferences.