Title : Unveiling thioredoxin inhibitor potential: Synthesis and characterization of thiazole compounds
Abstract:
Thioredoxin reductase (TrxR) is an enzyme that contains selenocysteine and is in charge of preserving redox equilibrium in cells. Despite having uses in other therapeutic areas such neurodegeneration, inflammation, microbial infections, and neonatal hyperoxic lung injury, TrxR has primarily been seen as a target for anticancer drugs. Moreover, from synthetic point of view, transition metal free, multicomponent approach is attracting utmost attention world-wide in modern organic chemistry. Hence, greener methodology is adopted for the synthesis of biologically important thiazole molecules. C-5 sulfenylated thiazoles are synthesized using thiophenols as Sulphur source and thiazoles in Iodine/DMSO at 90 ? [scheme1]. Excellent yields are obtained with easy workup methodology. Synthesized compounds were characterized via NMR, Mass spectroscopy and IR spectroscopy. Further, synthesized compounds were evaluated as thioredoxin reductase inhibitor and alpha amylase inhibitor.
Key words- thiazole, thiophenol, thiolation, iodine, DMSO, Thioredoxin inhibitor, alpha amylase inhibitor.
Audience Take Away:
- The audience from the presentation or discussion on "Unveiling Thioredoxin Inhibitor Potential: Synthesis and Characterization of Thiazole Compounds" can expect to learn several key points:
- Thioredoxin Inhibitors significance in various fields, such as medicine and biology
- Thiazole Compounds structure and properties
- Biological Applications of thiazole compounds can be applied in the context of thioredoxin inhibition. This may involve insights into potential medical or therapeutic applications
- Chemical Techniques and methods used in the synthesis and characterization of these compounds. This might include insights into laboratory procedures and analytical tools
Overall, the presentation on this topic aims to provide a comprehensive understanding of the synthesis and characterization of thiazole compounds and their potential as thioredoxin inhibitors, offering valuable knowledge to researchers, scientists, and professionals interested in this field.
- The presentation will likely touch on the broader implications of this research, including its potential impact on various scientific fields and its relevance to current research trends. Therefore, faculty could use to expand their research or teaching
- The audience might gain insights into potential future directions in this area of study, including ongoing research and potential applications in drug development or other industries
