Title : The role of chemistry in contribution to biomedicine recently
Abstract:
Recently, chemistry has made a significant contribution to the field of biomedicine.
Among the areas of biomedicine, chemistry is making a significant contribution to the anti-aging field, which aims to realize the dream of gene scissor therapy and life extension.
Measurements of analysis of cellular heterogeneity in gene expression are available by using a variant of flow cytometry based on fluorescence or light scattering to sort cells. This tool is based on molecular spectroscopy. Laser capture microdissection is helpful to identification that is coupled to a microscope and focused on a tissue.
Molecular mass spectrometry is contributed to RNA sequencing tool based on headspace solid-phase microextraction/gas chromatography-mass spectrometry.
Inflammation is one of the major causes of cellular senescence. Inflammatory aging is characterized by increased levels in the proinflammatory factors in the cells. The cell changes lead to the aging of the cells. Senescent fibroblasts and keratinocytes secrete a large number of senescent associated secretory phenotypes including the pro-inflammatory cytokines induce cell senescence by promoting the production of ROS and activating the ATM /p53/p21-signaling pathway.
Fibroblasts positive for SA-beta-gal activity and p16 expression are available to reveal immunofluorescent imaging to be identified the senescent fibroblasts.
Utilizing quantum theory in the field of biomedicine can help in understanding and applying treatments for a multitude of different disease or diverse types of cancer, and even expand upon efficient and reliable diagnosis in clinical settings.
Quantum chemistry gives an important explanation for subtle DNA changes and even telomere shortening in cancer patients. Using quantum chemistry in the field of biomedicine is available to understand and to apply treatments for multitude of different disease as Alzheimer’s disease and divers types of cancer, and to expand on efficient and reliable diagnosis in clinical treatments.
Computational chemistry’s tool is contributed to improve biomedicine drug development as molecular dynamics simulations and density functional theory. More recently, artificial intelligence connected to computational chemistry is largely contributed.
Quantum chemistry can provide valuable insights and a different perspective regarding the interaction between receptor and ligand in structure-based drug design, the holy grail of computational biomedicine drug discovery.
