Title : Nanotechnology for cancer treatment
Abstract:
Treatment of cancer using nanoparticle-based approaches being explored extensively to overcome the drawbacks associated with conventional treatment. Progress in nanotechnology for cancer therapy has led to the development of smart nanoformulations which improve the intracellular delivery of drugs due to their augmented multi-functionality and targeting potential. Smart nanoformulations are nano range particles which release the drug in accordance with the biological stimuli pre-existing at the disease site. This chapter summarizes most of the recent patents related to smart nano preparations for cancer therapy. Several polymeric nanoparticles were patented that destroy tumors by thermal energy deposition and thus enhance tumor therapy. Gold nanoparticles can absorb light strongly and convert photon energy into heat quickly and efficiently, escalating the temperature of a tumor cell (41°C – 141°C) and thus destroying cancerous cells. Specifically, coupling metallic nanoparticle properties with pH-sensitive targeting, resulted in an enhanced anti-tumor effect as observed in recently granted patents.