HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

4th Edition of

Chemistry World Conference

June 17-19, 2024 | Paris, France

Chemistry 2024

Eva Falomir Ventura

Speaker at Chemistry World Conference 2024 - Eva Falomir Ventura
Jaume I University, Spain
Title : Aryl azole derivatives as potential disruptors of tumor microenvironment


Thirty-nine aryl azoles, were synthesised and biologically evaluated for their activity as tumour microenvironment disruptors. Antiproliferative studies were performed in the tumour cell lines HT-29, A- 549 and MCF-7 and in the non-tumour cell line HEK-293. In HT-29, expression levels of biological targets involved in tumour microenvironment processes such as PD-L1, CD-47, c-Myc and VEGFR-2 were assessed. In addition, the antiproliferative activity was assessed when HT-29 were co-cultured with THP-1 monocytes and the secretion levels of IL-6 were also determined in these co-cultures. The angiogenic effect of some selected compounds on HMEC-1 was also evaluated as well as their effect on vasculogenic mimicry on HEK-293. Compounds with an amino group in the phenyl ring and a halogen atom in the benzyl ring showed promising results as tumour microenvironment disrupting agents. The most outstanding compound dramatically reduced the population of HT-29 cells when co-cultured with THP-1 monocytes and the levels of IL-6 secreted, as well as showing moderate effects on PD-L1, CD-47 and c-Myc.
Audience Take-Away:

  • Those people in the audience involved in Drug Discovery research could use most of the information we are going to provide.
  • This is a multidisciplinary and interdisciplinary work so people from research fields involved in Medicinal Chemistry, Biochemistry, Organic Chemistry, Cell biology, Immunology could be interested.
  • The audience will learn more about multitarget anticancer drug discovery for oncoimmunomodulating therapies.


Dr. Eva Falomir studied Chemistry at the Valencia University, Spain and graduated as MS in 1994. She then joined the research group of Prof. Carda at Jaume I University (UJI). She received her PhD degree in 1998 at the same institution. After two years postdoctoral fellowship supervised by Dr A. Fürstner at Max-Planck Institute, Germany she obtained the position of an Associate Professor at UJI. In 2022, she got a Full Professor position in the same university. She has published more than 100 research articles in SCI(E) journals.