HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

4th Edition of

Chemistry World Conference

June 17-19, 2024 | Paris, France

Chemistry 2023

Kaushala Prasad Mishra

Speaker at Chemistry World Conference 2023 - Kaushala Prasad Mishra
Bhabha Atomic Research Center, India
Title : Reactive oxygen species (ROS) act as chemical switch from supporting survival to death of cancer cells


Reactive oxygen species (ROS) are a group of highly reactive oxygen centred free radical chemical species in normal and cancer cells. In normal cells, ROS are maintained in tight control of level of the antioxidants. On the other hand, the level of ROS is generally elevated in cancer cells, due partly to metabolic activities and cell divisions, which are believed to play a critical role in the process of tumorigenesis and cancer progression.  It is further known that ROS can act as cancer suppressors depending on the varying antioxidant capacities of different types of cancers. These results suggest existence of a complex redox state in cancer cells, and they are regarded as intracellularly stressed.  In this talk, I will discuss the mechanisms of involvement of ROS and their functions in the initiation, signaling and proliferation of cancer cells. It is pointed out that the delicate balance of ROS and antioxidants levels determine their role in survival and death processes of cancer cells. This redox situation offers novel anticancer therapy strategies to achieve the goal of greater cancer cell killing by increasing the ROS level in response to anticancer therapies such as chemotherapy and radiotherapy.  It is concluded that ROS acts as a chemical switch from favouring survival to destruction of cancer cells improving radiotherapy in clinic. 


Prof Dr K.P. Mishra post graduated in Chemistry from University of Allahabad. He joined prestigious National Institute, Bhabha Atomic Research Center, Mumbai as Research Scientist in nuclear Science and Technology. He grew upwards from position to position and served  in the research field for more than 4 decades. He specialized in chemo-biolocal sciences, Free Radical Biology, Radiation and Cancer Biology, Biotechnology and Life Sciences.  He rose to the level of Senior Professor and remained HOD for many years.  He is serving on Editorial Boards of about a dozen reputed Journals. He has published more than 350 research papers in refereed reputed journals. He guided and mentored 51 Ph.D. students.