Abstract
About this talk
A small library of aryl triazole-scaffold derivatives have been developed using click chemistry synthetic strategies. Docking studies using PD-L1 and VEGFR-2 crystallographic data confirmed their potential targeted action. The antiproliferative activity on monocultures of several tumour cell lines (HT-29, A-549 and MCF-7), and on the non-tumour cell line HEK-293 has been studied. Also, the effect on anticancer targets (PD-L1, VEGFR-2 and c-Myc) has been evaluated. Finally, the effect on cancer cell viability when co-cultured with immune cells (Jurkat T cells or THP-1) has been also studied together with their effect on IL-6 secretion to cell media.
Audience Takeaway Notes:
- The audience will learn more about multitarget anticancer drug discovery for oncoimmunomodulating therapies.
- Those people in the audience involved in Drug Discovery research could use most of the information we are going to provide.
- This is a multidisciplinary and interdisciplinary work so people from research fields involved in Medicinal Chemistry, Biochemistry, Organic Chemistry, Cell biology, Immunology could be interested.
Speaker
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