N methyl N nitrosourea as a carcinogenic agent what is its potential

Title : N methyl N nitrosourea as a carcinogenic agent what is its potential

Abstract:

Animal models are essential for biomedical research. Using them, the researchers are able to better understand the diseases, and search for more effective prophylactic and therapeutic approaches. Rodents are among the most frequently used species for scientific purposes. Chemical carcinogens’ administration is one of the most frequently used methods to establish animal models of cancer. Indeed, these chemicals have the ability to induce cancer development in several organs. The carcinogen N-methyl-N-nitrosourea (MNU) is the oldest member of the nitroso compounds with the ability to alkylate DNA. So, MNU is classified as a complete, potent, and direct alkylating agent. Depending on the animals' species and strain, dose, route, and age at the administration, MNU may induce cancer development in several organs, like breast, ovary, uterus, prostate, liver, spleen, kidney, stomach, small intestine, colon, hematopoietic system, lung, skin, retina, and urinary bladder. This work intended to review the experimental conditions to the chemical induction of cancer development in several organs with this carcinogen agent, with a special emphasis in the mammary carcinogenesis.

Biography:

Ana Faustino is Professor at Department of Zootechnics of University of Évora and Researcher at CITAB/UTAD.  She holds a Master in Veterinary Medicine and a European PhD in Veterinary Sciences. Animal models of cancer, tumoral angiogenesis and imaging are her main areas of interest. She has collaborating in several Financed Research projects. The results of her works were published in more than 250 publications in several formats. She received several prizes of scientific merit, and highlights and press honors. She has experience in supervising graduate and post-graduate students. She participated in several courses, workshops, international and national meetings. She is editorial member of several scientific journals and reviewer of more than 300 manuscripts. She is Guest Editor of two special issues in Veterinary Animals and in Life.