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4th Edition of

Chemistry World Conference

June 17-19, 2024 | Paris, France

Chemistry 2022

Iwona Budziak Wieczorek

Speaker at Chemistry World Conference 2022 - Iwona Budziak Wieczorek
University of Life Science in Lublin, Poland
Title : Cocrystal Formation of Natural Flavonoids Synthesis, Physico Chemical Assessment, Antioxidant and Spectroscopic Studies


In recent years, special interest in the prevention and treatment of many civilization diseases is caused by polyphenol compounds that are widespread in the plant world. Dietary flavonoids exert various biological activities like cardioprotective, chemopreventive, and neuroprotective effects which are attributed to their antioxidant, anti-inflammatory, and signaling properties. However, their poor solubility in aqueous solutions and the associated limited bioavailability exclude the development of effective and stable pharmaceutical formulations or dietary supplements. A number of methods are known to improve the pharmacokinetic profile of bioactive compounds, for example, using salts, amorphous dispersions in a polymer matrix, an inorganic matrix as a carrier, nanoparticles, and cocrystals. Especially, crystal engineering and cocrystallization techniques appear as a promising way to modify the bioavailability (e.g., solubility, permeability, and stability) and other physicochemical properties for a wide range of bioactive compounds. Cocrystals are single phase materials composed of two or more different molecular and/or ionic compounds generally in a stoichiometric ratio, bound by noncovalent interactions, predominantly hydrogen bonds, which are neither solvates nor simple salts.

The aim of the presentation is to show the results including the development of the synthesis of new crystalline forms of (-)-epicatechin, (+)-catechin and cardamonin with commonly used coformers which are included in the list of compounds authorized for the safe use as additives to food products, pharmaceutical preparations, and dietary supplements. The chemical characteristics of the obtained cocrystals were confirmed by single crystal X-ray diffraction, FTIR, and Raman techniques. Structural studies were based mainly on the analysis of interactions occurring in the molecular structure, e.g. hydrogen bonds, π···π interactions and supramolecular synthons.


Mrs Iwona Budziak-Wieczorek graduated from the Faculty of Chemistry of the Jagiellonian University in Krakow in 2016. She works as a research assistant at the University of Life Sciences in the Department of Chemistry in Lublin (Poland). She wrote a doctoral thesis titled Bioavailability of natural bioactive compounds – physicochemical and model studies which is to be defended in 2022. She is interested in cocrystallization methods of natural flavonoids as well as solubility and permeability study. The purpose of her research is to synthesis new cocrystals of poorly water-soluble natural bioactive flavonoids. She has published 11 research articles in SCI(E) journals.