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3rd Edition of

Chemistry World Conference

June 14-15, 2023 | Rome, Italy

Chemistry 2022

A Comparative Study between Conventional and Advanced Extraction Techniques: Pharmaceutical and Cosmetic Properties of Plant Extracts

Speaker at Chemistry World Conference 2022 - Ez zouhra El Maaiden
African Sustainable Agriculture Research Institute, Morocco
Title : A Comparative Study between Conventional and Advanced Extraction Techniques: Pharmaceutical and Cosmetic Properties of Plant Extracts


Medicinal and aromatic plant (MAPs) extracts are attracting much attention because of their interesting phytochemical composition, leading to the development of new pharmacological and cosmetic drugs. Extraction represents a critical step in the itinerary of phytochemical discovery from MAPs. The type of extraction procedure used can substantially influence the final extract recovered. This study aimed to compare the influence of extraction methods on the pharmaceutical and cosmetic properties of medicinal and aromatic plants (MAPs). For this purpose, the dried plant materials were extracted using advanced (microwave (MAE), ultrasonic (UAE), and homogenizer (HAE) assisted extractions) and conventional techniques (maceration, percolation, decoction, infusion, and Soxhlet). The tyrosinase, elastase, α-amylase, butyryl, and acetylcholinesterase inhibition were tested by using L-3,4 dihydroxy-phenylalanine, N-Succinyl-Ala-Ala-p-nitroanilide, butyryl, and acetylcholine as respective substrates. Antioxidant activities were studied by ABTS, DPPH, and FRAP. In terms of extraction yield, advanced extraction techniques showed the highest values (MAE > UAE > HAE). Chemical profiles were dependent on the phenolic compounds tested, whereas the antioxidant activities were always higher, mainly in infusion and decoction as a conventional technique. In relation to the pharmaceutical and cosmetic properties, the highest inhibitory activities against α-amylase and acetylcholinesterase were observed for Soxhlet and macerated extracts, whereas the highest activity against tyrosinase was obtained with MAE > maceration > Soxhlet. Elastase and butyrylcholinesterase inhibitory activities were in the order of Soxhlet > maceration > percolation, with no activities recorded for the other tested methods. In conclusion, advanced methods afford an extract with high yield, while conventional methods might be an adequate approach for minimal changes in the biological properties of the extract.

Keywords: advanced extraction; conventional extraction; bioactive compounds; enzyme inhibition; oxidative stress; microwave-assisted extraction


Dr. EL maaiden EZzouhra is a Postdoctoral Reseacher at African Research Institute for Sustainable Agriculture (ASARI) of the Mohammed VI Polytechnic University (UM6P) in phytochemistry and Valorization of plant species by the production of high added value molecules for cosmetic and wellness. She earned his M.Sc. and Ph.D. degrees from the University of Hassan 1st University in Settat in 2016 and 2021, respectively. His ongoing research focuses on valorization of the biomass of medicinal and aromatic plants to discover and characterize new bioactive metabolites that could pave new avenues for cosmetics, nutraceutical, and pharmaceutical applications.