Abstract
About this talk
Ionophores are compounds that facilitate the transport of ions across cellular membranes, disrupting the normal ionic balance within cells. This disruption can lead to various cellular responses, including apoptosis (programmed cell death), making ionophores potential candidates in cancer therapy. Ion homeostasis is crucial for the survival of both normal and neoplastic cells. Disruptions in ion balance are characteristic of cancer cells, prompting the exploration of ionophores agents that modulate ion transport as potential anticancer treatments. Notable ionophores such as Valinomycin, Nigericin, and Obatoclax have demonstrated significant anticancer activities, particularly against cancer stem-like cells, which are often resistant to conventional therapies and contribute to tumor recurrence.
Keywords: Ionophores, homeostasis, neoplastic cells and anticancer activities etc.
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