Title : Symbiotic microorganisms, an inspirational model for the search of bioactive compounds
In nature insects and plants live in symbiosis with bacteria and fungi in order to protect themselves from their pathogens.1 These symbiotic microorganisms play a key role in the ecological success of their host. The ecological benefits they provide to their macroscopic host, offer information on the valorisation possibilities of their metabolites.2
On one hand, endophytes are microbes that inhabit host plants without causing disease and are reported to be a reservoir of metabolites that combat pathogens.3 On another hand, it has been shown that insects could protect themselves from microbial infections thanks to beneficial association with other microorganisms; insects use molecular defences from symbiotic these microbe.3
Consequently, endophytic and insect symbiotic microorganisms should - in order to ensure their spread - produce active compounds against pathogens like microbes or herbivores. Moreover, the genetic plasticity of microorganisms induces diverse chemical profiles even within the same species.3
Endophytes, entompathogens and microrganisms associated with insect were isolated and analyzed chemically and biologically, and many bioactive compounds could be identified.
Our studies show that microorganisms in symbiosis (mutualism or parasitism) with insects or plants can be a model for the search for antimicrobial compounds.
Audience take away:
• My area of research activity falls within the broad field of natural substances chemistry.
• Our objective is to explore the chemodiversity within a unique collection of diverse symbiotic strains. Our goal is to explore the chemodiversity of new resources, in order to discover compounds with pharmacological and / or agrochemical interest but also to understand the ecological role of biosynthesized compounds.
• For this purpose, different methodological tools such as chemical ecology, metabolomics and functional chemodiversity are used and developed. The goal of this research is to carry out integrated approaches for the study and valorization of secondary metabolites from an original resource of natural substance: symbiotic microorganisms.