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Chemistry World Conference

Sep 06-08, 2021 | Rome, Italy

Scopus Indexed Conference

Eparvier Veronique

Keynote Speaker for Chemistry 2020
Eparvier Veronique
Title : Symbiotic microorganisms, an inspirational model for the search of bioactive compounds


In nature insects and plants live in symbiosis with bacteria and fungi in order to protect themselves from their pathogens.1 These symbiotic microorganisms play a key role in the ecological success of their host. The ecological benefits they provide to their macroscopic host, offer information on the valorisation possibilities of their metabolites.2
On one hand, endophytes are microbes that inhabit host plants without causing disease and are reported to be a reservoir of metabolites that combat pathogens.3 On another hand, it has been shown that insects could protect themselves from microbial infections thanks to beneficial association with other microorganisms; insects use molecular defences from symbiotic these microbe.3
Consequently, endophytic and insect symbiotic microorganisms should - in order to ensure their spread - produce active compounds against pathogens like microbes or herbivores. Moreover, the genetic plasticity of microorganisms induces diverse chemical profiles even within the same species.3 
Endophytes, entompathogens and microrganisms associated with insect were isolated and analyzed chemically and biologically, and many bioactive compounds could be identified. 
Our studies show that microorganisms in symbiosis (mutualism or parasitism) with insects or plants can be a model for the search for antimicrobial compounds.

Audience take away:

•    My area of research activity falls within the broad field of natural substances chemistry. 
•    Our objective is to explore the chemodiversity within a unique collection of diverse symbiotic strains. Our goal is to explore the chemodiversity of new resources, in order to discover compounds with pharmacological and / or agrochemical interest but also to understand the ecological role of biosynthesized compounds.    
•    For this purpose, different methodological tools such as chemical ecology, metabolomics and functional chemodiversity are used and developed. The goal of this research is to carry out integrated approaches for the study and valorization of secondary metabolites from an original resource of natural substance: symbiotic microorganisms.


Véronique Eparvier is research engineer at CNRS, h-index: 14 (55 publications, 22 conference articles, 3 patents) - responsible of Microorganisms associated group at CNRS –“Institut de Chimie des Substances Naturelles”. She is graduated with two Master’s degrees: Sciences of Agro-resources (National Polytechnic Institute of Toulouse), and Anthropology (Laboratory of Human Ecology and Anthropology, Aix-Marseille III University) and since 2005 with a PhD, specialty “Chemistry of Natural Substances” from the National Museum of Natural History, and Habilitated to manage research from Paris-Saclay (HDR, since 2013).
V. Eparvier works mainly in natural product chemistry and chemical ecology. She remained for 5 years in French Guiana, at the CNRS-Guyane where she collaborated with the UMR Ecofog, Pasteur Institute and IRD. She has a strong experience in field collect, extraction, isolation and determination of natural compounds by chemical analysis and she has been studying symbiotic microorganisms for 10 years now. She is responsible of the “Microbe extracts library” of ICSN-CNRS and developed in her laboratory antimicrobial screening on pathogen microbe. She participated to the European AGROCOS project, FUNCHEM labex CEBA project (2013-2016), International ANR project SECIL for which she is the scientific correspondent for ICSN (2015-2019), Astrid ANR INNOVANTIBIO (2017- 2019) and she was Coordinator of European project FEDER Insecticide (2011-2014) for which she received a price and of the project BORDER financed by CEBA Labex (2017-2018). Her team is involved in the Laboratory of Excellence Centre d’E?tude de la Biodiversite? Amazonienne (CEBA), where she is member of the scientific committee since 2014. She his also contributor to LERMIT Labex (Laboratoire d’Excellence en Recherche sur le Me?dicament et l’Innovation The?rapeutique). 
She is also Member of “International Groupement research” GDRI INPCHEM (Integrative Natural Product Chemistry), GDR Mediatec (Médiation chimique dans l’environnement – Ecologie Chimique) and AFERP association (Association Francophone pour l’Enseignement et la Recherche en Pharmacognosie

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