Chemistry World Conference

Sep 06-08, 2021 | Rome, Italy

Scopus Indexed Conference
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Ashour. Saleh Eljamil

Speaker for Chemistry 2020
Ashour. Saleh Eljamil
University of Tripoli, Libya
Title : Effects of dietary saturated fat on serum cholesterol levels

Abstract:

It is well established that diet is the primary therapeutic approach for persons who are at increased risk of premature heart disease, as a result of having elevated serum cholesterol levels (more than 200 mg/dl). Many dietary recommendations have been published in the last five decades that have advised people to reduce their intake of total fat, saturated fat and cholesterol to improve their cholesterol level and decrease the risk of coronary heart disease (CHD). However, these recommendations have recently been challenged by claims that dietary fat, saturated fat and cholesterol do not affect serum cholesterol levels and the risk of CHD.
Dietary cholesterol as a “nutrient of concern” has been dropped by the Dietary Guidelines Advisory Committee (DGAC) report (2015), so as to accord with evidence that there is no appreciable relationship between dietary cholesterol and serum cholesterol or clinical cardiovascular disease (CVD). Moreover, the DGAC, placed no limit on total fat consumption. Although evidence for an association between saturated fat intake and CHD remains controversial, it is widely accepted that saturated fats can raise serum levels of total cholesterol (TC) which increase is reflected in the low-density lipoprotein (LDL) fraction. A meta-analysis (Siri-Tarino et al. 2010) of prospective cohort studies has indicated no association between saturated fat intake and CHD. While a randomized trial (Dreon et al. 1998) has found that intake of saturated fats decreases the small-dense LDL-cholesterol fraction but increases the large-buoyant LDL-cholesterol fraction. High levels of large-buoyant LDL fraction may be resistant to oxidation and anti-atherogenic and therefore protective against CHD, whereas the small-dense LDL fraction is more susceptible to oxidation, is pro-atherogenic, and high levels of this LDL fraction are associated with greater CHD risk. Hence, consumption of saturated fat may alter the ratio of these fractions and be protective against CHD.
In this paper I will review the major published effects of dietary fat, saturated fat and cholesterol on serum cholesterol levels and the increased risk of CHD.
 

Biography:

Prof: Ashour Saleh Eljamil was born and raised in Tripoli, Libya. He received his Ph.D. in 1988 from the Biochemistry Department, University College Dublin, National University of Ireland, where his interest in lipid biochemistry started.  In February 1989 he joined the Department of Biochemistry, Faculty of Medicine, University of Tripoli, Tripoli, Libya, where he is full professor and was head of department from 2005 to 2007. In 1991, he headed the Biochemistry Department at the Medical Laboratory of Salahudeen Hospital in Tripoli. He was director of Medical Laboratory Department and Biochemistry unit at Tripoli Medical Centre from 1996 to 2004. He has presented  papers at several  scientific meetings in  Dublin, Ireland (1986) and   was an invited speaker  at  International Conferences on Drug Discovery and Therapy in Dubai, UAE in  2012,  2013 and  2014, and made presentations on low density lipoprotein-cholesterol, cholesterol and diet ,and serum lipid patterns in type 2 diabetes mellitus.  Also plenary speaker, (Effects of Dietary Plant Polyunsaturated Fatty Acids), at The Maghrebian-Finnish Biotechnology Symposium (MFBS 2016). March 19-22, 2016 at Hammamet City, Tunisia. http://www.mfbs.info/
and plenary speaker, (Effects of Dietary Plant Polyunsaturated Fatty Acids), at The Maghrebian-Finnish Biotechnology Symposium (MFBS 2018). March 19-22, 2018 at Helsinki, Finland, http://mfbs-2018.info/.
 He has published papers on the effects of dietary polyunsaturated fatty acids and of pyridoxal-5-phosphate on platelet aggregation and on serum low density lipoprotein cholesterol, in international and regional journals. He has been a frequent visiting professor at Universities in Benghazi, Zawia, Sirte, and  Musrata, Libya. He is editorial member of more than international journal. Recently, he published his Lipid Biochemistry for Medical Sciences book by iuniverse in U.S.A.

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