Title : Synthesis, characterization, DFT calculations, and in vitro anticancer studies against HeLa Cells of Zinc(II) and Cd(II) complexes of Bis(4-(ethoxycarbonyl)phenyl)dithiocarbamate and 6-ethoxybenzothiazol)dithiocarbamate ligands
Zn(II) and Cd(ll) complexes of 4-(ethoxycarbonyl)phenyldithiocarbamate, (4-etphdtc), and 6-ethoxybenzothiazol)dithiocarbamate, (6-etbedtc), ligands were synthesized and characterized by elemental analysis and spectroscopic techniques. The complexes are represented as; [Zn(4-etphdtc)2], [Cd(4-etphdtc)2], [Zn(6-etbedtc)2], [Zn(6-etbedtc)2]. The spectroscopic data confirmed that in each complex, two of the dithiocarbamate anion ligand coordinate the central metal ion as a bidentate chelating ligand through the two sulfur atoms. The molecular structure of the complexes is distorted tetrahedral geometry with a moiety of MS4, where M is Zn(II) or Cd(II), around the central metal ion. The cytotoxic of the synthesized ligands and their complexes were tested against cervical cancer cells (HeLa) at several concentrations. The results showed that the two ligands and the complex [Cd(6-etbedtc)2] are lower cytotoxic than the anticancer cisplatin. the viability of the ligands and their complexes decrease ongoing from 1 μM to 500 μM, and the significant effect on HeLa cells is increased.
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- This research provides the audience with new compounds and their applications
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- Our compounds can be used in the medical area as anticancer agents
- This research share with the audience new methods of synthesis