3rd Edition of

Chemistry World Conference

June 14-15, 2023 | Online Event

Chemistry 2023

Mohammad Arshad

Speaker at Chemistry World Conference 2023 - Mohammad Arshad
Shaqra University, Saudi Arabia
Title : Synthesis, characterization, antimicrobial and molecular docking studies of thiazolidin-4-one derivatives fused with indole and pyrimidine moieties


A series of fifteen 2-substituted-3-(4-(pyridin-2-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-2-yl)thiazolidin-4-one, was prepared and characterized using analytical techniques like FT-IR, NMR (1H & 13C), and mass spectrophotometry. On screening, the compounds for antibacterial and antifungal potential, the findings portrayed to be the potent inhibitor of bacterial and fungal strains. The cytotoxicity of the prepared molecules was checked against HepG2 cells to calculate the percent viable cells, which was observed to be in the range of 70-81 % up to 100 µM.  The molecular docking assay was performed to assess the binding modes, the extent of the H-bond, and binding affinities against the receptor glucosamine-6-phosphatase (GlcN-6P) and lanosterol 14-alpha-demethylase. The findings portrayed that TYR 312, SER316, GLU396, LEU448, SER303, GLY398, and SER 401 were the only amino acids of GlcN-6P that formed the H-bond with the prepared molecules. Similarly, the residues GLC5, GLC6, GLC7, SER60, TYR63, THR104, ASP229, LEU230, SER249, SER251, THR 485 were the only amino acids of lanosterol 14-alpha-demethylase) that formed H-bond with the prepared molecules. The binding affinities for both receptors were found to be in the range of -8.5 to -6.3 kcal/mole (GlcN-6P), and -8.4 to -6.8 kcal/mole (lanosterol 14-alpha-demethylase).


Dr. Mohammad Arshad, has been awarded the Ph. D degree in January, 2014 on the thesis entitled “Novel heterocyclic compounds as potential therapeutic agents: Synthesis and Characterization” from Jamia Millia Islamia, India. He has published more than 60 research article and presented his work in various National/ International seminars and conferences. He has been awarded the national fellowships from University Grant Commission, Govt of India and Council for Scientific and Industrial Research, Govt of India.Currently, he is working as a Senior Faculty Member and Coordinator, Research and Development Unit, College of Medicine, Dawadmi, Shaqra University, KSA. He has worked on many projects as Principal Investigator granted by Shaqra University, Saudi Arabia and organized many research activities at the college like Research Methodology workshops and Annual research Day. He is associated as the Guest editor, Editorial board Member, and Reviewer board member for many journals. He is the member of prominent scientific bodies like Indian Science Congress Association, Royal society of Chemistry, Americal Chemical Society.