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2nd Edition of

Chemistry World Conference

June 13-14, 2022 | Rome, Italy

Chemistry 2022

Targeting Out of Range Biomolecules Chemical Labeling Strategies for Qualitative and Quantitative MS based Detection

Speaker at Chemistry World Conference 2022 - Sonia Cantel
University of Montpellier, France
Title : Targeting Out of Range Biomolecules Chemical Labeling Strategies for Qualitative and Quantitative MS based Detection

Abstract:

In health sciences and particularly in –omics approaches, Mass spectrometry is of strategic importance for the detection and identification of specific molecules involved in biological processes, leading to a better understanding of physiological and physiopathological processes and consequently for diagnosis purposes. However, a large number of these relevant biomarkers remain undetectable due to several parameters, a low molecular weight, a weak abundance, their ionization potential or their localization in a complex environment. To overcome these limitations, labeling strategies have been developed. MS labeling require the development of diverse tags as versatile as possible, involving innovative chemistry, and targeting different functional groups such as amine, hydroxy groups or carboxylic acids. Specific probes, such as ABP have been designed to selectively label biomolecules of interest and to match the current need for in vivo labeling methods following the development of imaging techniques.

Audience take-away:

  • This lecture recapitulates recent derivatization methods and available labeling reagents while putting into perspective the importance of MS labels in the biochemical research context.
  • This multidisciplinary investigation addresses chemical synthesis, analysis and biological issues  

Biography:

Sonia Cantel obtained her PhD in 2004 in Chemistry of Biomolecules from the University of Montpellier, under the supervision of Dr. J-A Fehrentz, in the field of pseudo-peptide and solid phase organic synthesis. Then, she joined the group of Pr. M. Chorev for the following two years as a Post-doctoral Fellow in the Laboratory for Translational Research (Harvard Medical School, Boston, USA). She actively participated to biomedicinal projects where chemistry plays a critical role but also required the input of other scientific disciplines. In this interdisciplinary research environment, she developped extensive skills in analytical techniques applied to peptide and protein engineering. Her accomplishments included development of new methodologies for synthesis of glycated antigenic peptides and in situ templated assembly of fragments to generate potent inhibitors of protein-protein interaction.

She joined in 2007 the group of Professor J. Martinez as an Assistant-Professor at the University of Montpellier, taking advantage of her multidisciplinary experience to develop new projects at the interface of Chemistry, Biology and Analytical Sciences.

She focuses her research on the development of chemical probes for specific and sensitive detection of peptides and proteins, and pharmacological studies (GPCR/ligand interaction) by MALDI Mass Spectrometry.

Actively involved in peptide research environment, she is currently president of the GFPP (Groupe Francais des Peptides et Protéines).

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